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Filling the GOCE data gap unearths South Pole’s geological past

Filling the GOCE data gap unearths South Pole’s geological past

It’s very difficult to know what lies beneath a blanket of kilometres-thick ice, so it is hardly surprising that scientists have long contested the shape and geology of the ancient supercontinent from which East Antarctica formed over a billion years ago. An ESA-funded study can now lay some of this conjecture to rest. Using sensors on aircraft to measure changes in the gravity and magnetic signatures of the different rocks under the ice, scientists have discovered a huge bay the size of the UK formed part of the edge of East Antarctica.

Agenzia spaziale Europea Space 13 Mar 2022
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Smooth sailing for young crew

Smooth sailing for young crew

Young people from nine countries learn to sail and work together thanks to EU youth programme

Rockitalia Entertainment 17 Nov 2008
190.0K 0
Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Resp

Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Resp

Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells.Sabrina Rotolo 1, Simona Ceccarelli 1, Ferdinando Romano 1, Luigi Frati 1,2, Cinzia Marchese 1, Antonio Angeloni 1* 1 Dipartimento di Medicina Sperimentale, Universita` Sapienza di Roma, Roma, Italy, 2 Istituto Neurologico Mediterraneo ‘‘Neuromed, Pozzilli, ItalyAbstract : BackgroundKeratinocyte growth factor receptor (KGFR) is a splice variant of the FGFR2 gene expressed in epithelial cells. Activation of KGFR is a key factor in the regulation of physiological processes in epithelial cells such as proliferation, differentiation and wound healing. Alterations of KGFR signaling have been linked to the pathogenesis of different epithelial tumors. It has been also hypothesized that its specific ligand, KGF, might contribute to the development of resistance to 5-fluorouracil (5-FU) in epithelial cancers and tamoxifen in estrogen-positive breast cancers.Abstract : Methodology/Principal FindingsSmall interfering RNA was transfected into a human keratinocyte cell line (HaCaT), a breast cancer derived cell line (MCF-7) and a keratinocyte primary culture (KCs) to induce selective downregulation of KGFR expression. A strong and highly specific reduction of KGFR expression was observed at both RNA (reduction = 75.7%, P = 0.009) and protein level. KGFR silenced cells showed a reduced responsiveness to KGF treatment as assessed by measuring proliferation rate (14.2% versus 39.0% of the control cells, P

Redazione Health 03 Jul 2008
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