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Trovati 9 risultati per "function"
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Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast
• Otx2 binds to the promoter/enhancer region of Oct4, Sox2, and Nanog in ESCs and EpiSCs • Otx2 binding to the Nanog promoter helps maintain the integrity of ESC compartments • Loss of this Otx2-binding site induces primed-like features in ESCs • Otx2 regulation of Nanog contributes to ICM differentiation of the epiblast Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, including Otx2, recently have been shown to function during the transition from naive to primed pluripotency. Here we uncover a role for Otx2 in the control of the naive pluripotent state. We analyzed Otx2-binding activity in ESCs and EpiSCs and identified Nanog, Oct4, and Sox2 as direct targets. To unravel the Otx2 transcriptional network, we targeted the strongest Otx2-binding site in the Nanog promoter, finding that this site modulates the size of specific ESC-subtype compartments in cultured cells and promotes Nanog expression in vivo, predisposing ICM differentiation to epiblast. Otx2-mediated Nanog regulation thus contributes to the integrity of the ESC state and cell lineage specification in preimplantation development.
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Bimbo di due anni,salvato per il suo coraggio da una morte certa.
Bimbo di due anni fermo nelle acque torrenziali, salvato per il suo coraggio
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Cubase SX 2.0 and VST 2.3 audio architecture
The heart of Cubase SX 2.0 is the fantastic-sounding 32-bit floating point audio engine incorporating the latest VST 2.3 audio architecture. Offering full 6-channel surround, complete plug-in delay compensation throughout, an unprecedented level of user friendliness, and over other 100 new functions, Cubase SX 2.0 sets new standards in music production software for Mac and PC.
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POWER MAC G4 - 15 Gigaflops of Creative Power
With a quantum leap in processing power, ultraefficient system architecture, next-generation 3D graphics, the revolutionary DVD-R/CD-RW-burning SuperDrive and Mac OS X, the dual 1GHz Power Mac G4 is designed to put your workflow into fast forward.
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